Opportunity for catch-up HPV vaccination in young women after first delivery.

Rama, C.H., Villa, L.L., Pagliusi, S., Andreoli, M.A., Costa, M.C., Thomann, P., Alves, V.A.F., Longatto-Filho, A., & Eluf-Neto, J., (2010). Opportunity for catch-up HPV vaccination in young women after first delivery. Journal of Epidemiology and Community Health, 64(7), 610-615.

Background: Early age at first delivery has been identified as a risk factor for high-risk HPV-type infection and cervical cancer development.

Methods: A cross-sectional study was carried out in a large public maternity hospital in São Paulo, Brazil. During June 2006 to February 2007, 301 women aged 15-24 years who gave birth to their first child were recruited between 43 and 60 days after delivery. Detection of HPV DNA in cervical specimens was performed using a standardised PCR protocol with PGMY09/11 primers. The association of selected factors with HPV infection was assessed by using a Generalised Linear Model.

Results: HPV DNA was detected in 58.5% (95% CI 52.7% to 64.0%) of the enrolled young women. The most common types of HPV found were: HPV16, HPV51, HPV52, HPV58 and HPV71. The overall prevalence of HPV types targeted by the HPV prophylactic vaccines was: HPV 16-12.0%, HPV 18-2.3% and HPV 6 and 11 4.3%. In the multivariate analysis, only age (inversely, p for trend=0.02) and smoking habits were independently associated with HPV infection.

Conclusions: The findings show that these young primiparous women had high cervical HPV prevalence, suggesting that this is a high-risk group for cervical cancer development. Nevertheless, 17.3% were positive for any of the four HPV types included in HPV vaccines (HPV6, 11, 16 or 18), with 13.3% positive for HPV 16 or 18 and only 1.0% having both vaccine related-oncogenic HPV types. Thus, young primiparous women could benefit from catch-up HPV vaccination programmes.

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