Pilot testing of an HIV medication adherence intervention in a public clinic in the Deep South.
Konkle‐Parker, D. J., Erlen, J. A., Dubbert, P. M., & May, W. (2012). Pilot testing of an HIV medication adherence intervention in a public clinic in the Deep South. Journal of the American Academy of Nurse Practitioners, 24(8), 488–498.
Purpose: Strict adherence to HIV medications is critical to ensure long‐term disease control, and adherence interventions that are possible in a clinic setting with limited resources are needed.
Data sources: This randomized controlled pilot study tested an adherence intervention guided by the Information‐Motivation‐Behavioral Skills (IMB) model. The intervention included HIV education, a peer video, motivational interviewing, and attention to behavioral skills including communication with providers and adherence‐enhancing devices. Dependent variables included 3‐4 week adherence recall, medication refill rate, changes in IMB subscale scores, appointment attendance, and HIV‐associated laboratory findings. Seventy‐three individuals starting or restarting antiretroviral therapy were enrolled and 56 were randomized.
Conclusions: Improvements were seen in most outcomes, with small to moderate effect sizes, but the study was not powered to show statistical significance. Threats to power included a 51% attrition rate, resulting mostly from loss to clinical care or prolonged gaps in care.
Implications for practice: A telephone‐based intervention to improve HIV medication adherence shows promise. Further study is needed with greater attention to retention in care.
